Références scientifiques

Sleep Loss and Alzheimer’s Disease : Mechanisms, Risk Factors, and Cognitive Consequences

Antoniya Hachmeriyan, and Lili Grudeva

Sommeil

J. Dement. Alzheimer’s Dis. 2026, 3, 47 · 2026

DOI : https://doi.org/10.3390/jdad3040047

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Vitamin D supplement intake is associated with better cognition in persons with sleep disturbance and mild cognitive impairment

Sirui Zhou 1 , Paul Sudeshna 2 , Lynn Marie Trotti 3 , Donald Bliwise 4 , Victoria Pak 5

Alimentation

Sleep Med . 2026 Oct:146:108960. · 2026

DOI : 10.1016/j.sleep.2026.108960

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Obstructive sleep apnoea and Alzheimer’s disease pathology: a review of plausible pathological mechanisms and potential modifying impact of hypertension

Georgina Rawson, Mark E Howard, Matthew P Pase , Melinda L Jackson

Sommeil

Sleep Med . 2026 Oct 6:149:109307. · 2026

DOI : 10.1016/j.sleep.2026.109307.

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Lithium deficiency and the onset of Alzheimer’s disease

Liviu Aron, Zhen Kai Ngian, Chenxi Qiu, Jaejoon Choi, Marianna Liang, Derek M Drake, Sara E Hamplova, Ella K Lacey , Perle Roche, Monlan Yuan, Saba S Hazaveh, Eunjung A Lee, David A Bennett, Bruce A Yankner

Alimentation

Nature . 2025 Sep;645(8081):712-721 · 2025

DOI : https://doi.org/10.1038/s41586-025-09335-x

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Exploring the skin as an open window onto neurodegenerative diseases

Francesca Lozzi 1 , Emanuela Camera 1 , Giorgia Cardinali 2 , Anna Di Nardo

Environnement

Transl Neurodegener . 2025 Nov 27;14(1):61 · 2025

DOI : 10.1186/s40035-025-00522-4

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Volatile Organic Compounds (VOCs) in Neurodegenerative Diseases (NDDs)

Jolanda Palmisani 1 , Antonella Maria Aresta 1 , Viviana Vergaro 2 , Giovanna Mancini 1 , Miriana Cosma Mazzola

Environnement

Molecules . 2025 Oct 9;30(19):4028 · 2025

DOI : 10.3390/molecules30194028

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Gut Fungi in Alzheimer’s Disease: Mechanisms, Biomarkers and Therapeutic Potential

Ziyu Liu, Zhuo Chen, Xiaoyan Zhang, Yi Ge, Duo Yuan, Huihong Zhai

Environnement

Aging Dis . 2025 May 6;17(3):1484-1499 · 2025

DOI : 10.14336/AD.2024.1310

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Lithium deficiency and the onset of Alzheimer’s disease

Alimentation

Nature 2025 Sep;645(8081):712-721 · 2025

DOI : 10.1038/s41586-025-09335-x

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Assessing the Relationship Between the Flicker Test and Cognitive Performance

Natalia D Mankowska 1 , Rita I Sharma 2 , Anna B Marcinkowska 1 3 , Jacek Kot 4 , Pawel J Winklewski

Technologies

Biology (Basel) . 2025 Oct 22;14(11) · 2025

DOI : https://doi.org/10.3390/biology14111469

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Hypertension and Alzheimer’s disease: Pathological interplay, comorbidity risks, and new strategies for synergistic management

Xinyu Weia, Lili Lib, Guohua Zhaoa, Yani Luana, Qian Wangc and Wenjing Ninga

Cardiovasculaire

CLINICAL AND EXPERIMENTAL HYPERTENSION 2025, VOL. 47, NO. 1, 2595154 · 2025

DOI : https://doi.org/10.1080/10641963.2025.2595154

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Physical exercise-mediated neuroprotective mechanisms in Parkinson’s disease, Alzheimer’s disease, and epilepsy

R A Pinho 1 2, A P Muller 3, L F Marqueze 1, Z Radak 4, R M Arida

Activité physique

Braz J Med Biol Res . 2024 Nov 25:57:e14094 · 2024

DOI : 10.1590/1414-431X2024e14094

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Sustained Cognitive Improvement in Alzheimer’s Disease Patients Following a Precision Medicine Protocol

Dale E Bredesen , Mary Kay Ross , Stephen Ross

Technologies

Biomedicines . 2024 Aug 6;12(8):1776 · 2024

DOI : https://doi.org/10.3390/biomedicines12081776

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Microglial Activation in Metal Neurotoxicity: Impact in Neurodegenerative Diseases

María I Martínez-Hernández 1, Leonor C Acosta-Saavedra 1, Luisa C Hernández-Kelly 1, Jaqueline Loaeza-Loaeza 1, Arturo Ortega

Environnement

Biomed Res Int . 2023 Jan 31:2023:7389508 · 2023

DOI : 10.1155/2023/7389508

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Tracing the Path between Mushrooms and Alzheimer’s Disease-A Literature Review

Ana Margarida Silva 1, Marco Preto 2, Clara Grosso 3, Mónica Vieira 1 4, Cristina Delerue-Matos 3, Vitor Vasconcelos 2 5, Mariana Reis 2, Lillian Barros 6 7, Rosário Martins

Alimentation

Molecules . 2023 Jul 24;28(14):5614. · 2023

DOI : 10.3390/molecules28145614

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The roles of fungus in CNS autoimmune and neurodegeneration disorders

Chuyu Wu 1 2 , Mei-Ling Jiang 1 , Runqui Jiang 1 , Tao Pang 2 , Cun-Jin Zhang

Environnement

Front Immunol . 2023 Jan 26:13:1077335 · 2023

DOI : https://doi.org/10.3389/fimmu.2022.1077335

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Rationale for a Multi-Factorial Approach for the Reversal of Cognitive Decline in Alzheimer’s Disease and MCI

Rammohan V Rao, Kaavya G Subramaniam, Julie Gregory, Aida L Bredesen, Christine Coward, Sho Okada, Lance Kelly, Dale E Bredesen

Technologies

Int J Mol Sci . 2023 Jan 14;24(2):1659. · 2023

DOI : https://doi.org/10.3390/ijms24021659

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Precision Medicine Approach to Alzheimer’s Disease: Successful Pilot Project

Kat Toups, Ann Hathaway, Deborah Gordon, Henrianna Chung, Cyrus Raji, Alan Boyd, Benjamin D Hill

Technologies

J Alzheimers Dis . 2022;88(4):1411-1421 · 2022

DOI : 10.3233/JAD-215707

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A new diagnostic approach in Alzheimer’s disease: The critical flicker fusion threshold

Azar Abiyev 1 , Funda Datlı Yakaryılmaz 2 , Zeynel Abidin Öztürk 3

Technologies

Dement Neuropsychol . 2022 Jan-Mar;16(1):89-96 · 2022

DOI : https://doi.org/10.1590/1980-5764-dn-2021-0054

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Precision Medicine Approach to Alzheimer’s Disease : Successful Pilot Project

Kat Toups 1 , Ann Hathaway 2 , Deborah Gordon 3 , Henrianna Chung 4 , Cyrus Raji 5 , Alan Boyd 6 , Benjamin D Hill 7 , Sharon Hausman-Cohen 8 , Mouna Attarha 9 , Won Jong Chwa 10 , Michael Jarrett 4 , Dale E Bredesen

Technologies

J Alzheimers Dis . 2022;88(4):1411-1421. · 2022

DOI : https://doi.org/10.3233/jad-215707

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Association Between Obstructive Sleep Apnea, Its Treatment, and Alzheimer’s Disease

Chih-Yun Kuo 1,*, Hung-Ta Hsiao 2, Ing-Hsien Lo 2, Tomas Nikolai 1

Sommeil

Frontiers in Aging Neuroscience · 2021

DOI : 10.3389/fnagi.2020.591737

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Cognitive Effects of Aerobic Exercise in Alzheimer’s Disease: A Pilot Randomized Controlled Trial

Fang Yu 1, David M Vock 1, Lin Zhang 1, Dereck Salisbury 2, Nathaniel W Nelson 3, Lisa S Chow 4, Glenn Smith 5, Terry R Barclay 6, Maurice Dysken 4, Jean F Wyman

Activité physique

J Alzheimers Dis . 2021;80(1):233-244. · 2021

DOI : 10.3233/JAD-201100

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Case Study : A Precision Medicine Approach to Multifactorial Dementia and Alzheimer’s Disease

Mary Kay Ross, Cyrus Raji, Kristine L Lokken, Dale E Bredesen , Jared C Roach , Cory C Funk , Nathan Price , Noa Rappaport , Leroy Hood , James R Heath

Technologies

J Alzheimers Dis Parkinsonism . 2021;11(Suppl 5):018 · 2021

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Cardiovascular Risk Factors Across the Life Course and Cognitive Decline

Kristine Yaffe 1 , Eric Vittinghoff 2 , Tina Hoang 2 , Karen Matthews 2 , Sherita H Golden 2 , Adina Zeki Al Hazzouri

Cardiovasculaire

Neurology . 2021 Apr 27;96(17):e2212-e2219 · 2021

DOI : 10.1212/WNL.0000000000011747

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Obstructive sleep apnea, cognition and Alzheimer’s disease: A systematic review integrating three decades of multidisciplinary research

Omonigho M Bubu 1, Andreia G Andrade 2, Ogie Q Umasabor-Bubu 3, Megan M Hogan

Sommeil

Sleep Med Rev . 2020 Apr:50:101250. · 2020

DOI : 10.1016/j.smrv.2019.101250

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Impaired cerebral blood flow in type 2 diabetes mellitus – A comparative study with subjective cognitive decline, vascular dementia and Alzheimer’s disease subjects

Anson C M Chau 1 , Eva Y W Cheung 2 , K H Chan 3 , W S Chow 4 , Y F Shea 5 , Patrick K C Chiu 5 , Henry K F Mak

Cardiovasculaire

Neuroimage Clin . 2020:27:102302 · 2020

DOI : 10.1016/j.nicl.2020.102302

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Environmental toxins and Alzheimer’s disease progression

Maryam Vasefi 1, Ehsan Ghaboolian-Zare 2, Hamzah Abedelwahab 2, Anthony Osu

Environnement

Neurochem Int . 2020 Dec:141:104852 · 2020

DOI : 10.1016/j.neuint.2020.104852

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Heavy Metals Exposure and Alzheimer’s Disease and Related Dementias

Kelly M Bakulski 1, Young Ah Seo 2, Ruby C Hickman 1, Daniel Brandt 1, Harita S Vadari 1, Howard Hu 3, Sung Kyun Park

Environnement

J Alzheimers Dis . 2020;76(4):1215-1242 · 2020

DOI : 10.3233/JAD-200282

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Hypertension and Cognitive Decline : Implications of Obstructive Sleep Apnea

Meghna P Mansukhani, Bhanu Prakash Kolla, Virend K Somers

Cardiovasculaire

Front Cardiovasc Med. 2019 Jul 10;6:96 · 2019

DOI : 10.3389/fcvm.2019.00096

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Gut microbiota and neuroinflammation in cognitive ageing

Cryan J.F., O'Riordan K.J., Cowan C.S.M. et al.

Alimentation

Physiological Reviews · 2019 · vol. 99 · n° 4 · p. 1877-2013

DOI : 10.ertert.dfdgf

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Metal Toxicity Links to Alzheimer’s Disease and Neuroinflammation

Tee Jong Huat 1, Judith Camats-Perna 2, Estella A Newcombe 2, Nicholas Valmas 3, Masashi Kitazawa 4, Rodrigo Medeiros

Environnement

J Mol Biol . 2019 Apr 19;431(9):1843-1868 · 2019

DOI : 10.1016/j.jmb.2019.01.018

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Reversal of Cognitive Decline: 100 Patients

Ann Hathaway8, Mary Braud16, Patricia Henry16, Ilene Naomi Rusk

Technologies

J Alzheimers Dis Parkinsonism 2018, Vol 8(5): 450 · 2018

DOI : 10.4172/2161-0460.1000450

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Association between midlife vascular risk factors and estimated brain amyloid deposition

Rebecca F Gottesman 1 , Andrea L C Schneider 2 , Yun Zhou 3 , Josef Coresh 4 , Edward Green 5 , Naresh Gupta 6 , David S Knopman

Cardiovasculaire

JAMA . 2017 Apr 11;317(14):1443-1450. · 2017

DOI : 0.1001/jama.2017.3090.

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Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort

Rebecca F Gottesman 1 2 , Marilyn S Albert 1 , Alvaro Alonso 3 , Laura H Coker 4 , Josef Coresh 2 , Sonia M Davis

Cardiovasculaire

JAMA Neurol. 2017 Oct 1;74(10):1246-1254 · 2017

DOI : https://doi.org/10.1001/jamaneurol.2017.1658

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Environmental risk factors for dementia: a systematic review

Lewis O J Killin, John M Starr, Ivy J Shiue, Tom C Russ

Environnement

BMC Geriatr . 2016 Oct 12;16(1):175 · 2016

DOI : 10.1186/s12877-016-0342-y

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Reversal of cognitive decline in Alzheimer’s disease

Dale E Bredesen 1 2 , Edwin C Amos 3 , Jonathan Canick 4 , Mary Ackerley 5 , Cyrus Raji 6 , Milan Fiala 7 , Jamila Ahdidan

Technologies

Aging (Albany NY) . 2016 Jun;8(6):1250-8 · 2016

DOI : 10.18632/aging.100981

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Different Brain Regions are Infected with Fungi in Alzheimer’s Disease

Diana Pisa 1 , Ruth Alonso 1 , Alberto Rábano 2 , Izaskun Rodal 2 , Luis Carrasco

Environnement

Sci Rep . 2015 Oct 15:5:15015. · 2015

DOI : 10.1038/srep15015

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Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration

Arati A. Inamdar, Muhammad M. Hossain, Alison I. Bernstein

Environnement

Proc Natl Acad Sci U S A . 2013 Nov 26;110(48):19561-6 · 2013

DOI : https://doi.org/10.1073/pnas.1318830110

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Vascular risk factors: a ticking time bomb to Alzheimer’s disease

Jack C de la Torre

Cardiovasculaire

Am J Alzheimers Dis Other Demen . 2013 Sep;28(6):551-9 · 2013

DOI : 10.1177/1533317513494457

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Arsenic, Cadmium, Lead, and Mercury in Sweat: A Systematic Review

Margaret E Sears, Kathleen J Kerr, Riina I Bray

Environnement

J Environ Public Health . 2012 Feb 22;2012:184745 · 2012

DOI : https://doi.org/10.1155/2012/184745

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Sleep-disordered breathing and cognitive decline in older adults

Yaffe K., Laffan A.M., Harrison S.L. et al.

Sommeil

JAMA · 2011 · vol. 306 · n° 6 · p. 613-619

DOI : 10.ertert.dfdgf

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Critical Flicker Fusion Threshold in patients with Alzheimer’s disease and vascular dementia

Stephen Curran 1 , Simon Wilson, Shabir Musa, John Wattis

Technologies

Int J Geriatr Psychiatry . 2004 Jun;19(6):575-81 · 2004

DOI : https://doi.org/10.1002/gps.1134

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Critical flicker fusion threshold: a potentially useful measure for the early detection of Alzheimer’s disease

Stephen Curran 1 , John Wattis

Technologies

Hum Psychopharmacol . 2000 Mar;15(2):103-112. · 2000

DOI : https://doi.org/10.1002/(sici)1099-1077(200003)15:2103::aid-hup1493.0.co;2-7

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Role of diet and exercise in aging, Alzheimer’s disease, and other chronic diseases

Sachi Khemka, Aananya Reddy, Ricardo Isaiah Garcia, Micheal Jacobs, Ruhananhad P. Reddy, Aryan Kia Roghani, Vasanthkumar Pattoor, Tanisha Basu, Ujala Sehar, P. Hemachandra Reddy

Alimentation

Ageing Res Rev. 2023 November ; 91: 102091 · 1968

DOI : 10.1016/j.arr.2023.102091.

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Sleep abnormalities across different clinical stages of Alzheimer’s disease

Ye Zhang a, Rong Ren a , Xujun Feng a , Meiou Wang a , Jiaxue Huang a , Jie Shi b, Lin Lu b , Larry D. Sanford c, Michael V. Vitiello d, Xiangdong Tang

Sommeil

Sleep Medicine Reviews Volume 88, August 2026, 102289

DOI : https://doi.org/10.1016/j.smrv.2026.102289

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Vitamin deficiencies and Alzheimer’s disease

Mariya Timotey Miteva 1,2†, Davide Laurenti 3†, Roberto Mattioli Daniel Di Risola 3*, Alessia Mariano 3‡ and Luciana Mosca 3‡

Alimentation

Frontiers in Nutrition

DOI : https://doi.org/10.3389/fnut.2026.1676497

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